"Experiments on Embryonic Induction III. A Note on Inductions by Chick Primitive Streak Transplanted to the Rabbit Embryo" (1934), by Conrad Hal Waddington

Conrad Hal Waddington?s ?Experiments on Embryonic Induction III,? published in 1934 in the Journal of Experimental Biology, describes the discovery that the primitive streak [7] induces the mammalian embryo. Waddington?s hypothesis was that a transplanted primitive streak [7] could induce neural tissue in the ectoderm [8] of the rabbit [9] embryo. The primitive streak [7] defines the axis of an embryo and is capable of inducing the differentiation [10] of various tissues in a developing embryo during gastrulation [11]. In this experiment Waddington was, in fact, able to induce neural differentiation [10]. Waddington noted that the tissue is ?competent? for a chick [12] organizer [13], and by deduction a mammalian organizer [13] must exist. Competence refers to a cell's ability to respond to an inducing signal, which is temporally limited to certain developmental stages [14]. Waddington?s initial work laid the foundation for many decades of research to follow, including further experiments by Waddington with the mammalian organizer [13].